Fixtures (306)
| Date | Home | Score | Away | FT | HT | |
|---|---|---|---|---|---|---|
| 15 May 2022 | Darmstadt | 3 – 0 | Paderborn | H | 3–0 | → |
| 15 May 2022 | Dresden | 0 – 1 | Erzgebirge Aue | A | 0–0 | → |
| 15 May 2022 | Hannover | 3 – 2 | Ingolstadt | H | 1–1 | → |
| 15 May 2022 | Hansa Rostock | 2 – 3 | Hamburg | A | 1–0 | → |
| 15 May 2022 | Heidenheim | 2 – 0 | Karlsruhe | H | 2–0 | → |
| 15 May 2022 | Nurnberg | 1 – 2 | Schalke 04 | A | 0–1 | → |
| 15 May 2022 | Sandhausen | 3 – 1 | Holstein Kiel | H | 3–0 | → |
| 15 May 2022 | St Pauli | 2 – 0 | Fortuna Dusseldorf | H | 0–0 | → |
| 15 May 2022 | Werder Bremen | 2 – 0 | Regensburg | H | 1–0 | → |
| 08 May 2022 | Erzgebirge Aue | 0 – 3 | Werder Bremen | A | 0–0 | → |
| 08 May 2022 | Holstein Kiel | 3 – 0 | Nurnberg | H | 2–0 | → |
| 08 May 2022 | Karlsruhe | 2 – 2 | Dresden | D | 0–1 | → |
| 07 May 2022 | Hamburg | 2 – 1 | Hannover | H | 2–1 | → |
| 07 May 2022 | Ingolstadt | 0 – 0 | Hansa Rostock | D | 0–0 | → |
| 07 May 2022 | Regensburg | 0 – 2 | Heidenheim | A | 0–0 | → |
| 07 May 2022 | Schalke 04 | 3 – 2 | St Pauli | H | 0–2 | → |
| 06 May 2022 | Fortuna Dusseldorf | 2 – 1 | Darmstadt | H | 2–0 | → |
| 06 May 2022 | Paderborn | 2 – 0 | Sandhausen | H | 1–0 | → |
| 30 Apr 2022 | Dresden | 1 – 1 | Regensburg | D | 0–0 | → |
| 30 Apr 2022 | Hansa Rostock | 0 – 0 | Paderborn | D | 0–0 | → |
| 30 Apr 2022 | Ingolstadt | 0 – 4 | Hamburg | A | 0–2 | → |
| 30 Apr 2022 | Darmstadt | 6 – 0 | Erzgebirge Aue | H | 4–0 | → |
| 29 Apr 2022 | Hannover | 2 – 0 | Karlsruhe | H | 1–0 | → |
| 29 Apr 2022 | Heidenheim | 1 – 3 | Fortuna Dusseldorf | A | 0–2 | → |
| 29 Apr 2022 | Sandhausen | 1 – 2 | Schalke 04 | A | 0–0 | → |
| 29 Apr 2022 | St Pauli | 1 – 1 | Nurnberg | D | 0–0 | → |
| 29 Apr 2022 | Werder Bremen | 2 – 3 | Holstein Kiel | A | 2–1 | → |
| 24 Apr 2022 | Erzgebirge Aue | 2 – 2 | Hansa Rostock | D | 2–1 | → |
| 24 Apr 2022 | Nurnberg | 2 – 4 | Sandhausen | A | 1–1 | → |
| 24 Apr 2022 | Paderborn | 3 – 0 | Hannover | H | 2–0 | → |
| 23 Apr 2022 | Holstein Kiel | 1 – 1 | Heidenheim | D | 0–0 | → |
| 23 Apr 2022 | Regensburg | 2 – 4 | Hamburg | A | 0–1 | → |
| 23 Apr 2022 | Schalke 04 | 1 – 4 | Werder Bremen | A | 0–2 | → |
| 23 Apr 2022 | St Pauli | 1 – 2 | Darmstadt | A | 0–2 | → |
| 22 Apr 2022 | Fortuna Dusseldorf | 2 – 2 | Dresden | D | 2–0 | → |
| 22 Apr 2022 | Karlsruhe | 2 – 2 | Ingolstadt | D | 0–1 | → |
| 17 Apr 2022 | Darmstadt | 2 – 5 | Schalke 04 | A | 2–3 | → |
| 17 Apr 2022 | Hansa Rostock | 1 – 1 | Regensburg | D | 1–0 | → |
| 17 Apr 2022 | Heidenheim | 0 – 2 | Erzgebirge Aue | A | 0–0 | → |
| 17 Apr 2022 | Ingolstadt | 0 – 1 | Paderborn | A | 0–0 | → |
| 17 Apr 2022 | Werder Bremen | 1 – 1 | Nurnberg | D | 0–1 | → |
| 16 Apr 2022 | Dresden | 0 – 0 | Holstein Kiel | D | 0–0 | → |
| 16 Apr 2022 | Hannover | 0 – 0 | Fortuna Dusseldorf | D | 0–0 | → |
| 16 Apr 2022 | Sandhausen | 1 – 1 | St Pauli | D | 0–1 | → |
| 16 Apr 2022 | Hamburg | 3 – 0 | Karlsruhe | H | 2–0 | → |
| 10 Apr 2022 | Holstein Kiel | 1 – 0 | Hamburg | H | 1–0 | → |
| 10 Apr 2022 | Paderborn | 2 – 2 | Karlsruhe | D | 1–1 | → |
| 10 Apr 2022 | Sandhausen | 2 – 1 | Dresden | H | 1–0 | → |
| 09 Apr 2022 | Erzgebirge Aue | 1 – 3 | Hannover | A | 0–2 | → |
| 09 Apr 2022 | Schalke 04 | 3 – 0 | Heidenheim | H | 1–0 | → |
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