Fixtures (306)
| Date | Home | Score | Away | FT | HT | |
|---|---|---|---|---|---|---|
| 26 Feb 2022 | St. Gilloise | 0 – 0 | Eupen | D | 0–0 | → |
| 26 Feb 2022 | Mechelen | 2 – 2 | Cercle Brugge | D | 2–2 | → |
| 26 Feb 2022 | Oostende | 0 – 0 | St Truiden | D | 0–0 | → |
| 26 Feb 2022 | Oud-Heverlee Leuven | 0 – 0 | Anderlecht | D | 0–0 | → |
| 25 Feb 2022 | Beerschot VA | 2 – 3 | Charleroi | A | 1–1 | → |
| 23 Feb 2022 | Gent | 4 – 0 | Seraing | H | 3–0 | → |
| 20 Feb 2022 | Antwerp | 1 – 2 | Mechelen | A | 0–2 | → |
| 20 Feb 2022 | Eupen | 1 – 3 | Club Brugge | A | 0–1 | → |
| 20 Feb 2022 | Anderlecht | 2 – 0 | Genk | H | 2–0 | → |
| 20 Feb 2022 | St Truiden | 2 – 0 | Oud-Heverlee Leuven | H | 1–0 | → |
| 19 Feb 2022 | Cercle Brugge | 2 – 0 | Beerschot VA | H | 2–0 | → |
| 19 Feb 2022 | Kortrijk | 5 – 0 | Waregem | H | 2–0 | → |
| 19 Feb 2022 | Oostende | 1 – 0 | Standard | H | 1–0 | → |
| 19 Feb 2022 | Charleroi | 0 – 3 | St. Gilloise | A | 0–2 | → |
| 16 Feb 2022 | Genk | 4 – 1 | Mechelen | H | 1–0 | → |
| 13 Feb 2022 | Genk | 2 – 0 | Standard | H | 1–0 | → |
| 13 Feb 2022 | St. Gilloise | 0 – 1 | St Truiden | A | 0–0 | → |
| 13 Feb 2022 | Club Brugge | 2 – 0 | Charleroi | H | 1–0 | → |
| 13 Feb 2022 | Beerschot VA | 2 – 1 | Kortrijk | H | 2–1 | → |
| 12 Feb 2022 | Eupen | 0 – 1 | Gent | A | 0–1 | → |
| 12 Feb 2022 | Mechelen | 3 – 0 | Oostende | H | 1–0 | → |
| 12 Feb 2022 | Oud-Heverlee Leuven | 3 – 2 | Cercle Brugge | H | 1–2 | → |
| 12 Feb 2022 | Waregem | 1 – 2 | Anderlecht | A | 0–2 | → |
| 11 Feb 2022 | Seraing | 0 – 1 | Antwerp | A | 0–0 | → |
| 09 Feb 2022 | Waregem | 0 – 0 | Oostende | D | 0–0 | → |
| 09 Feb 2022 | Oud-Heverlee Leuven | 2 – 1 | Genk | H | 1–1 | → |
| 06 Feb 2022 | Club Brugge | 1 – 2 | Gent | A | 0–1 | → |
| 06 Feb 2022 | Mechelen | 3 – 2 | Beerschot VA | H | 3–0 | → |
| 06 Feb 2022 | Anderlecht | 4 – 1 | Eupen | H | 3–1 | → |
| 06 Feb 2022 | Genk | 2 – 0 | Waregem | H | 1–0 | → |
| 05 Feb 2022 | Kortrijk | 1 – 3 | St Truiden | A | 0–2 | → |
| 05 Feb 2022 | Oostende | 1 – 3 | Oud-Heverlee Leuven | A | 0–1 | → |
| 05 Feb 2022 | Standard | 1 – 1 | Cercle Brugge | D | 0–1 | → |
| 05 Feb 2022 | Antwerp | 0 – 2 | St. Gilloise | A | 0–0 | → |
| 04 Feb 2022 | Charleroi | 2 – 0 | Seraing | H | 1–0 | → |
| 02 Feb 2022 | Kortrijk | 0 – 2 | Antwerp | A | 0–1 | → |
| 30 Jan 2022 | St. Gilloise | 1 – 0 | Anderlecht | H | 1–0 | → |
| 30 Jan 2022 | Gent | 0 – 1 | Antwerp | A | 0–1 | → |
| 30 Jan 2022 | Standard | 1 – 2 | Mechelen | A | 1–0 | → |
| 30 Jan 2022 | Kortrijk | 0 – 1 | Club Brugge | A | 0–0 | → |
| 29 Jan 2022 | Beerschot VA | 3 – 3 | Waregem | D | 1–3 | → |
| 29 Jan 2022 | Seraing | 0 – 0 | Eupen | D | 0–0 | → |
| 29 Jan 2022 | Cercle Brugge | 0 – 1 | Oostende | A | 0–0 | → |
| 28 Jan 2022 | St Truiden | 0 – 1 | Charleroi | A | 0–1 | → |
| 27 Jan 2022 | Club Brugge | 0 – 0 | St. Gilloise | D | 0–0 | → |
| 26 Jan 2022 | Eupen | 0 – 2 | Standard | A | 0–1 | → |
| 26 Jan 2022 | Waregem | 1 – 1 | Oud-Heverlee Leuven | D | 1–1 | → |
| 26 Jan 2022 | Anderlecht | 0 – 2 | Cercle Brugge | A | 0–0 | → |
| 26 Jan 2022 | Seraing | 2 – 1 | Beerschot VA | H | 1–0 | → |
| 25 Jan 2022 | Antwerp | 1 – 1 | St Truiden | D | 1–0 | → |