Fixtures (306)
| Date | Home | Score | Away | FT | HT | |
|---|---|---|---|---|---|---|
| 10 Apr 2022 | Charleroi | 3 – 0 | Waregem | H | 3–0 | → |
| 10 Apr 2022 | Club Brugge | 2 – 0 | Mechelen | H | 1–0 | → |
| 10 Apr 2022 | Gent | 5 – 0 | Oud-Heverlee Leuven | H | 1–0 | → |
| 10 Apr 2022 | Kortrijk | 2 – 3 | Anderlecht | A | 1–1 | → |
| 10 Apr 2022 | Seraing | 0 – 2 | Genk | A | 0–1 | → |
| 10 Apr 2022 | St. Gilloise | 5 – 0 | Beerschot VA | H | — | → |
| 10 Apr 2022 | St Truiden | 3 – 0 | Standard | H | 2–0 | → |
| 09 Apr 2022 | Eupen | 0 – 2 | Oostende | A | 0–1 | → |
| 09 Apr 2022 | Antwerp | 1 – 1 | Cercle Brugge | D | 0–0 | → |
| 03 Apr 2022 | Standard | 1 – 3 | St. Gilloise | A | 1–1 | → |
| 03 Apr 2022 | Cercle Brugge | 2 – 2 | Gent | D | 1–2 | → |
| 03 Apr 2022 | Anderlecht | 4 – 0 | Charleroi | H | 1–0 | → |
| 03 Apr 2022 | Genk | 5 – 0 | Eupen | H | 2–0 | → |
| 02 Apr 2022 | Waregem | 0 – 2 | St Truiden | A | 0–0 | → |
| 02 Apr 2022 | Mechelen | 3 – 2 | Kortrijk | H | 1–1 | → |
| 02 Apr 2022 | Oostende | 2 – 2 | Seraing | D | 1–1 | → |
| 02 Apr 2022 | Oud-Heverlee Leuven | 0 – 1 | Antwerp | A | 0–1 | → |
| 01 Apr 2022 | Beerschot VA | 1 – 3 | Club Brugge | A | 0–1 | → |
| 20 Mar 2022 | Club Brugge | 3 – 1 | Genk | H | 1–1 | → |
| 20 Mar 2022 | Kortrijk | 0 – 1 | Standard | A | 0–0 | → |
| 20 Mar 2022 | Gent | 1 – 0 | Anderlecht | H | 0–0 | → |
| 20 Mar 2022 | St Truiden | 3 – 2 | Beerschot VA | H | 2–1 | → |
| 19 Mar 2022 | Eupen | 1 – 1 | Mechelen | D | 1–1 | → |
| 19 Mar 2022 | Charleroi | 5 – 0 | Cercle Brugge | H | 4–0 | → |
| 19 Mar 2022 | Seraing | 1 – 1 | Oud-Heverlee Leuven | D | 0–0 | → |
| 19 Mar 2022 | Antwerp | 1 – 0 | Waregem | H | 0–0 | → |
| 18 Mar 2022 | St. Gilloise | 1 – 1 | Oostende | D | 0–1 | → |
| 13 Mar 2022 | Anderlecht | 2 – 1 | Antwerp | H | 1–1 | → |
| 13 Mar 2022 | Genk | 0 – 1 | St Truiden | A | 0–1 | → |
| 13 Mar 2022 | Beerschot VA | 0 – 2 | Gent | A | 0–1 | → |
| 13 Mar 2022 | Standard | 0 – 1 | Seraing | A | 0–0 | → |
| 12 Mar 2022 | Mechelen | 2 – 2 | Charleroi | D | 2–0 | → |
| 12 Mar 2022 | Cercle Brugge | 2 – 0 | Kortrijk | H | 0–0 | → |
| 12 Mar 2022 | Waregem | 3 – 0 | Eupen | H | 1–0 | → |
| 12 Mar 2022 | Oostende | 1 – 3 | Club Brugge | A | 1–2 | → |
| 11 Mar 2022 | Oud-Heverlee Leuven | 1 – 4 | St. Gilloise | A | 1–1 | → |
| 06 Mar 2022 | Antwerp | 2 – 1 | Beerschot VA | H | 0–1 | → |
| 06 Mar 2022 | Anderlecht | 3 – 0 | Oostende | H | 0–0 | → |
| 06 Mar 2022 | Charleroi | 0 – 0 | Standard | D | 0–0 | → |
| 06 Mar 2022 | Eupen | 3 – 1 | Oud-Heverlee Leuven | H | 1–1 | → |
| 06 Mar 2022 | Gent | 2 – 1 | Waregem | H | 1–0 | → |
| 05 Mar 2022 | Cercle Brugge | 2 – 2 | Genk | D | 1–0 | → |
| 05 Mar 2022 | Kortrijk | 2 – 3 | St. Gilloise | A | 1–1 | → |
| 05 Mar 2022 | Seraing | 0 – 5 | Club Brugge | A | 0–3 | → |
| 04 Mar 2022 | St Truiden | 1 – 1 | Mechelen | D | 0–1 | → |
| 02 Mar 2022 | Standard | 1 – 0 | Beerschot VA | H | 1–0 | → |
| 27 Feb 2022 | Club Brugge | 4 – 1 | Antwerp | H | 2–1 | → |
| 27 Feb 2022 | Genk | 2 – 0 | Kortrijk | H | 2–0 | → |
| 27 Feb 2022 | Standard | 0 – 1 | Gent | A | 0–0 | → |
| 27 Feb 2022 | Waregem | 1 – 0 | Seraing | H | 1–0 | → |
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