Fixtures (240)
| Date | Home | Score | Away | FT | HT | |
|---|---|---|---|---|---|---|
| 17 May 2022 | AEK | 2 – 3 | Olympiakos | A | 1–1 | → |
| 17 May 2022 | Giannina | 0 – 3 | Aris | A | 0–2 | → |
| 17 May 2022 | PAOK | 2 – 0 | Panathinaikos | H | 2–0 | → |
| 15 May 2022 | Asteras Tripolis | 2 – 2 | Apollon | D | 0–0 | → |
| 15 May 2022 | Ionikos | 3 – 1 | Panetolikos | H | 1–0 | → |
| 15 May 2022 | Lamia | 0 – 0 | Atromitos | D | 0–0 | → |
| 14 May 2022 | Volos NFC | 5 – 0 | OFI Crete | H | 3–0 | → |
| 14 May 2022 | Aris | 3 – 2 | AEK | H | 0–0 | → |
| 14 May 2022 | Olympiakos | 1 – 1 | PAOK | D | 1–1 | → |
| 14 May 2022 | Panathinaikos | 4 – 0 | Giannina | H | 1–0 | → |
| 11 May 2022 | PAOK | 0 – 1 | Aris | A | 0–0 | → |
| 11 May 2022 | AEK | 3 – 0 | Giannina | H | 2–0 | → |
| 11 May 2022 | Olympiakos | 1 – 2 | Panathinaikos | A | 0–1 | → |
| 08 May 2022 | OFI Crete | 1 – 0 | Asteras Tripolis | H | 0–0 | → |
| 08 May 2022 | Giannina | 1 – 0 | PAOK | H | 0–0 | → |
| 08 May 2022 | AEK | 0 – 0 | Panathinaikos | D | 0–0 | → |
| 08 May 2022 | Aris | 0 – 1 | Olympiakos | A | 0–0 | → |
| 07 May 2022 | Apollon | 0 – 0 | Lamia | D | 0–0 | → |
| 07 May 2022 | Atromitos | 0 – 1 | Ionikos | A | 0–0 | → |
| 07 May 2022 | Panetolikos | 0 – 0 | Volos NFC | D | 0–0 | → |
| 04 May 2022 | PAOK | 1 – 2 | Olympiakos | A | 1–0 | → |
| 02 May 2022 | Asteras Tripolis | 0 – 2 | Lamia | A | 0–1 | → |
| 02 May 2022 | Ionikos | 5 – 1 | Apollon | H | 2–0 | → |
| 01 May 2022 | Olympiakos | 3 – 2 | Giannina | H | 2–1 | → |
| 01 May 2022 | Panathinaikos | 1 – 0 | Aris | H | 1–0 | → |
| 01 May 2022 | PAOK | 1 – 1 | AEK | D | 1–1 | → |
| 30 Apr 2022 | OFI Crete | 0 – 1 | Panetolikos | A | 0–0 | → |
| 30 Apr 2022 | Volos NFC | 1 – 1 | Atromitos | D | 0–1 | → |
| 18 Apr 2022 | Giannina | 2 – 3 | AEK | A | 0–2 | → |
| 17 Apr 2022 | Atromitos | 1 – 1 | OFI Crete | D | 1–0 | → |
| 17 Apr 2022 | Lamia | 0 – 1 | Ionikos | A | 0–1 | → |
| 17 Apr 2022 | Aris | 1 – 0 | PAOK | H | 1–0 | → |
| 17 Apr 2022 | Panathinaikos | 1 – 0 | Olympiakos | H | 1–0 | → |
| 16 Apr 2022 | Apollon | 1 – 1 | Volos NFC | D | 0–0 | → |
| 16 Apr 2022 | Panetolikos | 0 – 0 | Asteras Tripolis | D | 0–0 | → |
| 10 Apr 2022 | Giannina | 0 – 0 | Panathinaikos | D | 0–0 | → |
| 10 Apr 2022 | AEK | 1 – 2 | Aris | A | 1–1 | → |
| 09 Apr 2022 | Volos NFC | 3 – 0 | Lamia | H | 0–0 | → |
| 09 Apr 2022 | OFI Crete | 1 – 2 | Apollon | A | 0–1 | → |
| 09 Apr 2022 | Asteras Tripolis | 2 – 3 | Ionikos | A | 1–2 | → |
| 09 Apr 2022 | Panetolikos | 2 – 3 | Atromitos | A | 2–2 | → |
| 03 Apr 2022 | Aris | 0 – 0 | Giannina | D | 0–0 | → |
| 03 Apr 2022 | Panathinaikos | 2 – 1 | PAOK | H | 1–0 | → |
| 03 Apr 2022 | Olympiakos | 1 – 1 | AEK | D | 1–1 | → |
| 02 Apr 2022 | Lamia | 1 – 2 | OFI Crete | A | 0–1 | → |
| 02 Apr 2022 | Asteras Tripolis | 0 – 0 | Atromitos | D | 0–0 | → |
| 02 Apr 2022 | Ionikos | 2 – 2 | Volos NFC | D | 1–0 | → |
| 02 Apr 2022 | Apollon | 1 – 0 | Panetolikos | H | 1–0 | → |
| 20 Mar 2022 | Giannina | 1 – 1 | Olympiakos | D | 0–1 | → |
| 20 Mar 2022 | Aris | 0 – 0 | Panathinaikos | D | 0–0 | → |
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