Fixtures (307)
| Date | Home | Score | Away | FT | HT | |
|---|---|---|---|---|---|---|
| 15 May 2022 | AZ Alkmaar | 1 – 3 | Waalwijk | A | 1–1 | → |
| 15 May 2022 | Feyenoord | 1 – 2 | Twente | A | 0–2 | → |
| 15 May 2022 | Groningen | 2 – 3 | Cambuur | A | 0–1 | → |
| 15 May 2022 | Heerenveen | 3 – 1 | Go Ahead Eagles | H | 1–0 | → |
| 15 May 2022 | Heracles | 1 – 3 | Sparta Rotterdam | A | 0–1 | → |
| 15 May 2022 | Nijmegen | 0 – 1 | For Sittard | A | 0–1 | → |
| 15 May 2022 | Vitesse | 2 – 2 | Ajax | D | 0–1 | → |
| 15 May 2022 | Willem II | 3 – 0 | Utrecht | H | 1–0 | → |
| 15 May 2022 | Zwolle | 1 – 2 | PSV Eindhoven | A | 1–1 | → |
| 11 May 2022 | Ajax | 5 – 0 | Heerenveen | H | 3–0 | → |
| 11 May 2022 | Cambuur | 1 – 1 | Willem II | D | 1–0 | → |
| 11 May 2022 | For Sittard | 1 – 2 | Vitesse | A | 1–1 | → |
| 11 May 2022 | Go Ahead Eagles | 0 – 1 | Feyenoord | A | 0–0 | → |
| 11 May 2022 | PSV Eindhoven | 3 – 2 | Nijmegen | H | 2–0 | → |
| 11 May 2022 | Sparta Rotterdam | 2 – 0 | Zwolle | H | 2–0 | → |
| 11 May 2022 | Twente | 3 – 0 | Groningen | H | 1–0 | → |
| 11 May 2022 | Utrecht | 2 – 2 | AZ Alkmaar | D | 1–2 | → |
| 11 May 2022 | Waalwijk | 2 – 0 | Heracles | H | 1–0 | → |
| 08 May 2022 | Nijmegen | 1 – 0 | Go Ahead Eagles | H | 0–0 | → |
| 08 May 2022 | AZ Alkmaar | 2 – 2 | Ajax | D | 0–1 | → |
| 08 May 2022 | Vitesse | 1 – 2 | Heerenveen | A | 1–0 | → |
| 08 May 2022 | Feyenoord | 2 – 2 | PSV Eindhoven | D | 0–2 | → |
| 07 May 2022 | Twente | 1 – 2 | For Sittard | A | 1–2 | → |
| 07 May 2022 | Willem II | 2 – 0 | Heracles | H | 2–0 | → |
| 07 May 2022 | Zwolle | 1 – 1 | Utrecht | D | 0–1 | → |
| 07 May 2022 | Groningen | 1 – 2 | Sparta Rotterdam | A | 0–1 | → |
| 06 May 2022 | Cambuur | 1 – 1 | Waalwijk | D | 0–0 | → |
| 01 May 2022 | Heerenveen | 3 – 3 | Cambuur | D | 2–1 | → |
| 01 May 2022 | Go Ahead Eagles | 1 – 2 | Vitesse | A | 1–1 | → |
| 01 May 2022 | PSV Eindhoven | 4 – 2 | Willem II | H | 3–1 | → |
| 01 May 2022 | For Sittard | 1 – 3 | Feyenoord | A | 0–2 | → |
| 01 May 2022 | Waalwijk | 3 – 1 | Groningen | H | 3–0 | → |
| 30 Apr 2022 | Ajax | 3 – 0 | Zwolle | H | 1–0 | → |
| 30 Apr 2022 | Heracles | 1 – 1 | Twente | D | 1–1 | → |
| 30 Apr 2022 | Sparta Rotterdam | 1 – 1 | AZ Alkmaar | D | 0–0 | → |
| 29 Apr 2022 | Utrecht | 1 – 0 | Nijmegen | H | 0–0 | → |
| 24 Apr 2022 | Willem II | 1 – 0 | Vitesse | H | 1–0 | → |
| 24 Apr 2022 | Feyenoord | 2 – 1 | Utrecht | H | 0–0 | → |
| 24 Apr 2022 | Groningen | 0 – 1 | Heracles | A | 0–1 | → |
| 24 Apr 2022 | For Sittard | 1 – 0 | Go Ahead Eagles | H | 1–0 | → |
| 23 Apr 2022 | Nijmegen | 0 – 1 | Ajax | A | 0–0 | → |
| 23 Apr 2022 | AZ Alkmaar | 2 – 1 | Heerenveen | H | 1–1 | → |
| 23 Apr 2022 | Waalwijk | 0 – 2 | Zwolle | A | 0–1 | → |
| 23 Apr 2022 | Cambuur | 1 – 2 | PSV Eindhoven | A | 1–1 | → |
| 22 Apr 2022 | Twente | 2 – 0 | Sparta Rotterdam | H | 1–0 | → |
| 19 Apr 2022 | Vitesse | 0 – 1 | Sparta Rotterdam | A | 0–1 | → |
| 16 Apr 2022 | For Sittard | 3 – 0 | Sparta Rotterdam | H | 2–0 | → |
| 10 Apr 2022 | Heerenveen | 3 – 1 | Groningen | H | 1–1 | → |
| 10 Apr 2022 | PSV Eindhoven | 2 – 0 | Waalwijk | H | 1–0 | → |
| 10 Apr 2022 | Vitesse | 1 – 0 | Cambuur | H | 1–0 | → |
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